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Sunday, January 1, 2012

Re Systemic Cyclosporin & Side Effects

Only use in conjunction with a specialist experienced in its use

Potential side effects
  • Raised BP
  • Hepatic dysfunction
  • Renal dysfunction

Pre-Rx check
  • BP
  • FBC; LFTs; UCEs; eGFR; lipids
  • Pregnancy test

If BP raised, consider 
  • Rx calcium-antagonist to prevent renal loss


Do Not Use if Pregnant or Planning Pregnancy

Systemic agents
  • Methotrexate
  • Acitretin (Neotigason)
  • Isotretinoin (RoAccutane)
  • Tetracyclines

Further more
  • Acitretin & Isotretinoin
    • No pregnancy within 2 years of Rx cessation

Re Systemic Methotrexate & Side Effects

Potential side effects

  • Hepatitis
  • Cytopenia
  • Teratogenesis
Pre-Rx check
  • LFTs; FBC; UCEs; eGFR
  • Pregnancy test

Re Systemic Prednisolone & Side-Effects

Short-term

  • Raised intra-occular pressure
  • Adrenal insufficiency

Long-term
  • As / short-term
  • Hypertension
  • Osteoporosis
  • Occular
    • Glaucoma
    • Cataracts
  • Endocrine
    • Diabetes
    • Electrolyte imbalance
  • Weight gain; tends to be trunk and face
Pre-Rx check
  • BP
  • Intraoccular pressure
  • LFTs; UCEs; eGFR; fasting lipids & BSL
Long-term Rx check
  • BP
  • Eyes - intraoccular pressure; cataracts
  • Bone density
  • UCEs; fasting lipids & BSL

Milia or Miliaria

Milia

  • Keratin-filled cysts


Miliaria
  • Blocked sweat ducts

Compression Bandages & Stockings for Wounds

Pressure

  • 18-24 mmHg
    • Jobst stockings
    • Varicose veins
    • Ulcer prevention
    • Mild edema
  • 25-35
    • Venosan stockings
    • Varicose veins (severe)
    • Post limb DVT
  • 14-17
    • If discomfort an issue with higher pressure / patient compliance
Should be properly measured

Wound Dressings

Examples of Brand Dressings for Different Types of Wounds


Venous

  • Zinc oxide
    • FlexiDress
    • Steripaste
Xs bacterial burden / Excessive moisture
  • Calcium alginate with antiseptic component (e.g. weak povidine-iodine)
    • Algisite M
    • Kaltostat
Hypergranulation
  • Hypertonic saine
    • Mesalt
    • Curasalt